There is a vast (and rapidly growing) amount of experimental and clinical data of the nervous system at very diverse spatial scales of activity (e.g. from sub-cellular through to whole organ), with many neurological disorders characterised by oscillations in neural activity across these disparate scales. Computer modelling and the development of associated mathematical theories provide us with a unique opportunity to integrate information from across these diverse scales of activity; leading to explanations of the potential mechanisms underlying the time-evolving dynamics and more importantly allowing the development of new hypotheses regarding neural function that may be tested experimentally and ultimately translated into the clinic. The purpose of this special issue is to present an overview of current integrative research in the areas of epilepsy, Parkinsons Disease and schizophrenia, where multidisciplinary relationships involving theory, experimental and clinical research are becoming increasingly established. (From the Editorial written by Stephen Coombes & John R. Terry, Guest Editors of this Special Issue)
The new Special Issue of EJN entitled “The Dynamics of Neurological Disease: Integrating Computational, Experimental and Clinical Neuroscience” has been published online. Click here to access full-text articles of the issue.
Interview video series
|Interview of Jonathan Rubin (University of Pittsburgh, USA), Contributor of the Special Issue (summary of the changes on neuronal activity that are associated with parkinsonism and overview of the Rubin/Terman computational model)||Access video|
|Interview of John R. Terry (University of Exeter, UK), Guest Editor of the Special Issue (overview of the Special Issue and summary of study on temporal evolution of focal-onset seizures in intracranial EEG recordings from patients with temporal lope epilepsy||Access video|