Featured article of EJN issue 36-7
Orbicia Riccio, Nicolas Hurni, Sahana Murthy, Laszlo Vutskits, Lutz Hein, Alexandre Dayer
Monoamines such as serotonin and dopamine regulate cortical interneuron migration but very little is known regarding noradrenaline. In this study we monitored the effects of adrenergic receptor stimulation on interneuron migration in cortical slices and found that adra2 receptor activation inhibits the migration of cortical interneurons in a concentration-dependent and reversible manner. Furthermore the distribution of cortical interneurons was altered in vivo in adra2a/2c knock-out mice.
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Access the corresponding commentary by John Parnavelas
|Dr. Alexandre Dayer is a SNSF-funded assistant professor at the Department of Mental Health and Psychiatry and affiliated to the Department of Basic Neuroscience at the Geneva Faculty of Medicine (Switzerland). He has done his postdoctoral training in the laboratory of Heather Cameron (NIMH, USA), where he studied adult neurogenesis. He then worked in the field of stem cells and brain repair in the laboratory of Prof. Jozsef Kiss in Geneva. In 2010 Dr Dayer obtained a SNSF-funded assistant professorship and his lab is currently working on the molecular programs that control the migration and specification of cortical neuron subtypes in psychiatric-relevant mouse models. The long term goal of his lab is to understand how altered genetic programs and activity-dependent processes can disrupt the migration and specification of specific neuronal subtypes and lead to abnormal cortical connectivity. Trained as an MD, Dr Dayer works as a part-time clinician in a specialized mood unit and has a strong interest in the developmental origin of psychiatric disorders. His lab is part of the NCCR-Synapsy (http://www.nccr-synapsy.ch/), a large-scale research initiative funded by the Swiss National Science Foundation aimed at addressing the neurobiological mechanisms of mental diseases.|