Interview of Vinay Parikh (Temple University, Philadelphia, PA, USA), corresponding author of the article “Diminished trkA receptor signaling reveals cholinergic-attentional vulnerability of aging”, first published online in EJN on December 11, 2012. Watch this interview to find out what we know on the role of NGF signalling on the structural integrity of cholinergic neurons in relation to Alzheimer’s Disease and how knocking down trkA receptors in the rat modeled key aspects of early stages of the disease.
Access the full-text article by Vinay Parikh, William M. Howe, Ryan M. Welchko, Sean X. Naughton, Drew E. D’Amore, Daniel H. Han, Monika Deo, David L. Turner and Martin Sarter